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目的 观察促红细胞生成素 ( EPO)对尿毒症患者中性粒细胞功能的影响。方法 分三组进行中性粒细胞墨汁吞噬试验、粘附试验和硝基兰四唑试验 ( NBT)。结果 三组吞噬率分别为 38 7%± 6 4%、 16 0 %± 5 1%和 2 1 9%± 6 3% ( P<0 0 5 ) ;粘附率分别为 67 6%±10 7%、 37 4%± 15 1%和 5 3 3%± 15 9% ( P<0 0 5 ) ;NBT阳性率分别为 4 3%± 2 7%、 3 6%± 2 9%和 5 8%± 4 5 % ( P>0 0 5 )。结论 尿毒症患者中性粒细胞功能受损 ,接受 EPO治疗后 ,其功能得到改善。
Objective To investigate the effect of erythropoietin (EPO) on neutrophil function in uremic patients. Methods Neutrophil ink phagocytosis test, adhesion test and nitro blue tetrazolium test (NBT) were divided into three groups. Results The phagocytic rates of the three groups were 38 7% ± 64%, 16 0% ± 5 1% and 21 9% ± 6 3%, respectively (P 0 05), and the adhesion rates were 67 6% ± 10 7 The positive rates of NBT were 43% ± 27%, 36% ± 29% and 58%, respectively. The positive rates of NBT were 37% ± 15% and 53% ± 15% ± 45% (P> 0.05). Conclusion Neutrophil dysfunction in patients with uremia, EPO treatment, its function improved.