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目的:报道1例原发于胸腺的非霍奇金氏恶性淋巴瘤,并结合文献探讨其临床及组织病理学特点。方法:对1例原发性胸腺非霍奇金氏恶性淋巴瘤进行常规病理及免疫组化观察。结果:显微镜下,肿瘤细胞大小较一致,排列密集,弥漫分布,核深染,圆形或卵圆形。免疫组织化学染色结果示:肿瘤细胞表达LCA、CD3、CD45RO、TdT及Vimentin,不表达CD79α、CD20、CD99、CD3、CD30、CD15、CD68、NSE、Syn、CgA、SCLC、CK、CK7及EMA。基因受体重排显示TCR基因发生克隆性重排。结论:原发性胸腺淋巴瘤极为罕见,临床诊断应排除白血病或其他部位淋巴瘤的转移。在日常临床工作中如遇到胸腺肿瘤,除胸腺较常见的肿瘤外,还应考虑淋巴瘤。
OBJECTIVE: To report a case of non-Hodgkin’s lymphoma originating in the thymus and to investigate its clinical and histopathological features in combination with the literature. Methods: One case of primary thymus non-Hodgkin’s lymphoma was studied by routine pathology and immunohistochemistry. Results: Under the microscope, the size of the tumor cells was more consistent, densely arranged, diffusely distributed, nuclear stained, round or oval. The results of immunohistochemistry showed that the tumor cells expressed LCA, CD3, CD45RO, TdT and Vimentin without expressing CD79α, CD20, CD99, CD3, CD30, CD15, CD68, NSE, Syn, CgA, SCLC, CK, CK7 and EMA. Gene rearrangements of genes show clonal rearrangements of TCR genes. CONCLUSIONS: Primary thymic lymphoma is extremely rare and clinical diagnosis should exclude leukemia or metastases from other parts of the lymphoma. In the daily clinical work such as thymic tumors, in addition to thymus more common tumors, lymphoma should also be considered.