论文部分内容阅读
储存红细胞在体外保存过程中经历了一系列形态、功能、新陈代谢的改变。近年来多项研究表明输注保存期长的红细胞会导致多种临床不良预后事件,如感染风险增加、肾衰竭、呼吸衰竭、多器官衰竭、深静脉血栓、死亡等,尤其是生理功能受累患者更易发生不良预后事件,但其具体机制目前尚不明确。FHb对NO的清除作用、TLR4信号通路的激活、免疫细胞功能抑制及铁超载等理论,从不同方面阐述了储存红细胞在体外长时间保存后对机体造成损伤的可能机制。
Storage of red blood cells in vitro preservation process has undergone a series of changes in morphology, function, metabolism. In recent years, a number of studies have shown that transfusion of long-term preservation of red blood cells can lead to a variety of clinical adverse prognostic events, such as increased risk of infection, renal failure, respiratory failure, multiple organ failure, deep venous thrombosis, death, especially in patients with physiological function involvement More prone to adverse prognosis, but the specific mechanism is not yet clear. FHb on the role of NO scavenging, TLR4 signaling pathway activation, immune cell function inhibition and iron overload theory, elaborated from different aspects of the storage of red blood cells in vitro after a long time to save the possible mechanism of damage.