雌激素对于女性机体发挥着广泛的生理作用,除了作用于生殖系统外,还作用于其他靶器官,包括骨骼、心血管、中枢神经、肝脏和皮肤及其附属物等,对这些器官的生长、发育和功能均发挥着重要的作用~([1])。绝经或其他原因造成的卵巢功能减退,可使雌激素缺乏,进而影响这些靶器官的发育和功能,应针对适宜人群,在医生指导下,采用相应的雌激素补充治疗。人体内雌激素有3种,包括雌二醇、雌酮和雌三醇,以雌二醇的生物活性最强。雌二醇有多种 Estrogen plays a wide range of physiological roles in the female body, in addition to the role of the reproductive system, but also on other target organs, including bone, cardiovascular, central nervous system, liver and skin and its appendages, the growth of these organs, Development and function all play an important role ~ ([1]). Menopausal or other causes of ovarian dysfunction, can make the lack of estrogen, thereby affecting the development and function of these target organs should be appropriate for the crowd, under the guidance of a doctor, the corresponding estrogen replacement therapy. There are three types of estrogen in the human body, including estradiol, estrone and estriol to estradiol strongest biological activity. There are many kinds of estradiol