论文部分内容阅读
目的观察氯胺酮在治疗士的宁诱发惊厥中的作用以及对定量药物脑电图(QPEEG)δ频段的影响。方法健康家兔50只随机分成生理盐水组(NS组)、氯胺酮1.25mg/kg(K1.25组)、2.5mg/kg(K2.5组)、5.0mg/kg(K5.0组)和苯巴比妥组5.0mg/kg(PB组),耳缘静脉注射士的宁0.25mg/kg(15s内注完)制作惊厥模型,一旦强直惊厥出现,立即静脉注射相应的治疗药物。观察各药对家兔的死亡率、强直持续期的影响,并连续监测脑电图,分析QPEEGδ频段功率谱的变化。结果氯胺酮各剂量组与NS和PB组相比,家兔强直持续期明显缩短(P<0.05,r=0.8696),死亡率为零。脑电图变化与行为学表现同步,NS组在给药后1～5min几乎所有脑区的δ频段脑电功率百分比较基础值显著降低(P<0.01)。PB组在1、2min时δ功率百分比较基础值降低(P<0.01),5min时顶枕区开始恢复。氯胺酮各剂量组在给药后多数观察脑区的δ频段功率百分比与基础值相比变化不大,除顶枕区外其他脑区的功率百分比在给药后1～5min均较NS组和PB组有所提高(P<0.01,P<0.05)。结论氯胺酮抗惊厥的作用主要通过维持额区和颞区脑电δ波频率,减少惊厥时痫性波发放。
Objective To investigate the role of ketamine in the treatment of seizure - induced seizures and its effect on quantitative Q - band electroencephalography (QPEEG) δ - band. Methods Fifty healthy rabbits were randomly divided into normal saline group (NS group), ketamine 1.25mg / kg (K1.25 group), 2.5mg / kg (K2.5 group), 5.0mg / kg The phenobarbital group 5.0mg / kg (PB group), the ear vein intravenous injection of strychnine 0.25mg / kg (15s within the note) produced convulsions model, once the tonic convulsions appear immediately intravenous injection of the appropriate drug. Observe the effect of each drug on rabbit mortality and duration of tetanus, and continuously monitor the EEG and analyze the power spectrum of QPEEGδ. Results Compared with NS and PB groups, the duration of tetanus duration was significantly shortened (P <0.05, r = 0.8696) and the mortality rate was zero in each ketamine dose group. EEG changes and behavioral performance of synchronization, NS group in 1 ~ 5min after administration of almost all brain regions of the δ-band EEG percentage was significantly lower than the baseline value (P <0.01). In the PB group, the percentage of δ power decreased at 1 and 2 min (P <0.01), and the parietal region began to recover after 5 min. Ketamine dose group after administration most of the brain area of the δ-band power percentage changed little compared with the base value, except for the suboccipital area in other brain areas of the power percentage 1 ~ 5min after administration than NS group and PB Group increased (P <0.01, P <0.05). Conclusions The anticonvulsant effect of ketamine can reduce the seizure frequency of seizures during seizure mainly by maintaining the frequency of the EEG waves in the frontal and temporal regions.