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目的：检测胎盘型谷胱甘肽S-转移酶(GST-π)在喉鳞状细胞癌、喉乳头状瘤、声带息肉的表达及意义。方法：病理诊断确诊的喉鳞状细胞癌标本34例，喉乳头状瘤31例，声带息肉38例，用免疫胶体金方法检测GST-π在喉肿瘤组织的表达。结果：34例喉鳞状细胞癌组织GST-π表达100％阳性，其中有3例化疗后表达强度增强；31例喉乳头状瘤组织12．9％弱阳性表达；38例声带息肉全部为阴性。结论：GST-π对喉部良、恶性肿瘤的检测及化疗耐药性的产生方面有重要意义。“,”Objective: The experiment is to study the expression of glutathione S-transferase (GST-π) in laryngeal tumors,suchas squamous cell cancer,papilloma and polyp. Methods: Expression of GST-π was studied immunohistochemically(glue-goldmethod) in routinely processed tissues from 34 eases of squamous cell cancer,31 cases of papilloma,38 cases of polyp of vocalcard. Results: The expression rates of GST-π in squamous cell cancer were 100%. The expression of GST-π in 3 eases ofsquamous cell cancer got stranger after chemical therapy. The expression rates of GST-π in papilloma were 12.9% but thestaining were light. All the larynx polyps were negative for GST-π. Conclusion: GST-π has the important significance for distinguishing benign and malignant tumors and producing chemotherapeutic resistance.