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目的通过比较支气管动脉灌注(BAI)化疗联合放射治疗与全身化疗联合放射治疗局部晚期非小细胞肺癌的疗效,探讨其应用价值。方法回顾性分析我院2008年1月至2012年1月收治入院的200例Ⅲ期非小细胞肺癌患者临床资料,根据治疗方法不同随机分为2个组:治疗组100例,行2~3次BAI后4~7d给予放射治疗;对照组100例,给予4~6个周期全身化疗,在第1个周期化疗后3~4d开始放射治疗,至下1个周期化疗开始时暂停放射治疗,使化疗与放射治疗交替进行。结果治疗组近期疗效明显优于对照组;毒副反应:化疗主要反应为血液学和消化道反应,放射治疗主要是放射性肺、纵隔、食管炎的表现。治疗组反应轻,患者耐受良好,顺利完成治疗。两组毒副反应发生率比较无统计学意义。结论 BAI联合放射治疗疗效与全身化疗联合放射治疗相似,但具有症状缓解快、毒副作用轻、治疗后患者体质状况下降不明显、患者依从性高、治疗周期短、治疗费用低等特点。
Objective To compare the efficacy of bronchial artery infusion (BAI) chemotherapy with radiotherapy and systemic chemotherapy combined with radiotherapy in the treatment of locally advanced non-small cell lung cancer. Methods The clinical data of 200 patients with stage Ⅲ non-small cell lung cancer admitted to our hospital from January 2008 to January 2012 were retrospectively analyzed. According to the different treatment methods, they were randomly divided into two groups: treatment group (n = 100) and treatment group (n = 2-3) Radiotherapy was given 4 to 7 days after BAI. 100 cases in the control group were given 4 to 6 cycles of systemic chemotherapy. Radiotherapy was started 3 to 4 days after the first cycle of chemotherapy, and radiation therapy was suspended at the beginning of the next cycle of chemotherapy. Make chemotherapy and radiotherapy alternate. Results The curative effect of the treatment group was obviously better than that of the control group. Toxic and side effects: The main reactions of chemotherapy were hematology and gastrointestinal reactions. The radiation therapy was mainly the manifestation of radioactive lung, mediastinum and esophagitis. Response to treatment group light, patients were well tolerated, the successful completion of treatment. The incidence of adverse reactions in the two groups was not statistically significant. Conclusions The efficacy of BAI combined with radiotherapy is similar to that of systemic chemotherapy combined with radiotherapy. However, the combination of BAI and radiotherapy has the advantages of quick response to symptoms, mild toxic and side effects, no significant decrease in physical status after treatment, high compliance, short treatment period and low cost of treatment.