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戊型病毒性肝炎患者肝脏病理发现:炎症细胞浸润以淋巴细胞和单核巨噬细胞为主,淋巴细胞与病变肝细胞密切接触。为进一步揭示细胞免疫在戊型病毒性肝炎发病中的作用,我们系统观测了42例戊型病毒性肝炎患者血清 sIL-2R、IL-6、IL-8的动态变化。资料与方法一、研究对象1993年5月～1996年4月收住的急性黄疸型肝炎,经检测戊型肝炎特异性 IgM、IgG 确诊的42例戊型病毒性肝炎患者,其重症型肝炎6例,男33例,女9例,平均年龄33.4岁(15～61岁)。正常对照采用健康献血员,检测 EBV、HAV、HCV 感染标志均为阴性。二、研究方法1.试剂:rHu-sIL-2R、IL-6、IL-8包被,酶标单克隆抗体,标准品,均由第四军医大学免疫学教研室金伯泉主任提供。
Liver pathology of patients with viral hepatitis E found that infiltration of inflammatory cells in the main lymphocytes and monocytes, lymphocytes and diseased liver cells in close contact. To further reveal the role of cellular immunity in the pathogenesis of hepatitis E, we systematically observed the dynamic changes of serum sIL-2R, IL-6 and IL-8 in 42 patients with viral hepatitis. Materials and Methods First, the research object May 1993 to April 1996 admitted to acute jaundice hepatitis, hepatitis E-specific IgM, IgG diagnosis of 42 cases of patients with viral hepatitis E, the severe hepatitis 6 Cases, 33 males and 9 females, with an average age of 33.4 years (15 to 61 years old). Normal controls used healthy blood donors to detect EBV, HAV, HCV infection markers were negative. Second, the research methods 1. Reagents: rHu-sIL-2R, IL-6, IL-8 coating, monoclonal antibody standard, standard, by the Immunology Department of Fourth Military Medical University Director Jin Boquan provide.