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应用SP免疫组化方法对25例鼻腔小圆细胞恶性肿瘤进行单（多）克隆抗体联合标记（细胞角蛋白Cytokeratin1：80，结蛋白Desmin1：80，神经元特异性烯醇化酶NSE1：80，白细胞共同抗原LCA1：80，以及S—100蛋白1：80），除2例标记呈阴性反应外，余23例中17例LCA呈强阳性反应，诊断为非何杰金氏恶性淋巴瘤（NHL）；Cytokeratin弱阳性4例；S－100弱阳性2例，其中1例为恶黑，另1例为嗅母。与原诊断比较，符合率仅为17．4％。17例NHL中16例诊断为本分化癌或恶性肿瘤。本研究表明鼻腔小圆细胞恶性肿瘤中大多数是NHL，免疫组化联合标记，可使诊断准确性大大提高。
Twenty-five cases of nasal round cell malignancies were immunohistochemically labeled with single (multi)clonal antibodies (cytokeratin Cytokeratin 1:80, desmin Desmin 1:80, neuron-specific enolase NSE 1:80, leukocytes Common antigens LCA1:80, and S-100 protein 1:80). In addition to the negative reactions in 2 cases, 17 of the remaining 23 cases showed a strong positive reaction to LCA. The diagnosis was non-Hodgkin’s lymphoma (NHL). Cytokeratin weakly positive in 4 cases; S-100 weak positive in 2 cases, including 1 case of black, and 1 case of olfactory mother. Compared with the original diagnosis, the compliance rate was only 17.4%. Among 16 cases of NHL, 16 were diagnosed as differentiated or malignant tumors. This study showed that the majority of nasal round cell malignancies are NHL, immunohistochemistry combined with markers, can greatly improve the diagnostic accuracy.