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本实验研究了硒（Ｓｅ）和维生素Ｅ（ＶＥ）对大鼠血液流变学、血栓素（ＴＸＡ２）、前列环素（ＰＧＩ２）的影响。结果表明，饲以低Ｓｅ和低ＶＥ粮大鼠红细胞变形性、ＰＧＩ２水平降低，红细胞压积、红细胞聚集性、红细胞聚集指数、ＴＸＡ２水平、ＴＸＡ２／ＰＧＩ２比值升高，谷胱甘肽过氧化物酶和超氧化物歧化酶活力降低，脂质过氧化物含量增高。补充Ｓｅ或ＶＥ及Ｓｅ＋ＶＥ对纠正上述变化有相似而又不尽相同的效果，以联合补充效果好。结果提示，Ｓｅ和ＶＥ不足可能通过两个途径：（１）间接途径─—花生四烯酸代谢产物ＴＸＡ２、ＰＧＩｅ水平；（２）直接途径──Ｓｐｅｃｔｒｉｎ与红细胞变形性，影响血液流变性能及微循环功能，可能参与缺血缺氧性心肌损害的发病环节。
The present study investigated the effects of selenium (Se) and vitamin E (VE) on the hemorrheology, TXA2 and PGI2 in rats. The results showed that erythrocyte deformability, PGI2 level decreased, hematocrit, erythrocyte aggregation, erythrocyte aggregation index, TXA2 level and TXA2 / PGI2 ratio were increased in rats fed low Se and low VE diet. Glutathione peroxides Enzymes and superoxide dismutase activity decreased, lipid peroxides increased. Replenishment of Se or VE and Se + VE has similar and different effects to correct the above changes, so that the combined effect is good. The results suggest that Se and VE deficiencies may be through two pathways: (1) Indirect pathway ─ ─ arachidonic acid metabolites TXA2, PGIe levels; (2) Direct pathway ─ ─ specificity and erythrocyte deformability, and affect the blood rheological properties and Microcirculation may be involved in the pathogenesis of hypoxic-ischemic myocardial damage.