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目的:探讨上海郊区自然人群餐后2 h血糖水平与肱踝脉搏波传导速度(BaPWV)的相关性。方法:在上海市嘉定区选取2519名居民,对其进行问卷调查、体格检查、血和尿的生化检查以及BaPWV的检测,按餐后2 h血糖值四分位分组,分析餐后2 h血糖水平与BaPWV的相关性,以及动脉硬化患病情况。结果:1随着餐后2 h血糖水平的升高,4组BaPWV值总体呈显著增高趋势,分别为(1429.85±401.90)、(1425.70±383.31)、(1594.77±403.23)、(1709.11±399.05)cm/s;动脉硬化患病率依次升高,分别为15.40%、16.42%、27.97%、40.57%,组间趋势明显(趋势P<0.0001)。2Pearson相关分析显示,餐后2 h血糖水平与BaPWV正相关(r=0.255 14,P<0.0001);多元回归分析显示,餐后2 h血糖是BaPWV的独立危险因素(β=0.0906,P=0.0008)。3多元Logistic回归分析显示,在校正性别、年龄、体质量指数(BMI)、腰围、收缩压、舒张压、血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDL-C)、空腹胰岛素、空腹血糖、糖化血红蛋白(HbA1c)后,与餐后2 h血糖值下四分位组比较,第3、4分位组动脉硬化的患病风险逐渐升高,比值比(OR)[95%可信区间(CI)]分别为1.669(1.098~2.539)、1.713(1.094~2.682),趋势P=0.0036。结论:上海市嘉定区人群中,餐后2 h血糖是动脉硬化的独立危险因素。
Objective: To investigate the correlation between plasma glucose levels and brachial-ankle pulse wave velocity (BaPWV) after 2 h in Shanghai suburbs natural population. Methods: A total of 2519 inhabitants were selected from Jiading District of Shanghai City. Questionnaires, physical examinations, biochemical tests of blood and urine, and BaPWV were performed. The patients were divided into two groups according to the blood glucose level at 2h after meal, The level of association with BaPWV, and the prevalence of atherosclerosis. Results: 1 With the increase of blood glucose level at 2 h after meal, the BaPWV values in 4 groups increased significantly (1429.85 ± 401.90), (1425.70 ± 383.31), (1594.77 ± 403.23) and (1709.11 ± 399.05) cm / s. The prevalence of atherosclerosis increased in turn, which was 15.40%, 16.42%, 27.97% and 40.57%, respectively. The trend was significant (trend P <0.0001). 2Pearson correlation analysis showed that there was a positive correlation between BaPWV and BaPWV at 2h after meal (r = 0.25514, P <0.0001). Multiple regression analysis showed that postprandial blood glucose at 2h was an independent risk factor for BaPWV (β = 0.0906, P = 0.0008 ). (3) Logistic regression analysis showed that there was no significant difference in gender, age, body mass index (BMI), waist circumference, systolic blood pressure, diastolic blood pressure, serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol , High-density lipoprotein cholesterol (HDL-C), fasting insulin, fasting blood glucose and glycosylated hemoglobin (HbA1c), compared with the quartile at 2 h postprandial blood glucose The odds ratio (OR) [95% confidence interval (CI)] were 1.669 (1.098-2.539) and 1.713 (1.094-2.682) respectively, with a trend of P = 0.0036. Conclusion: Among the population of Jiading District in Shanghai, 2-h postprandial blood glucose is an independent risk factor for atherosclerosis.