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一种蝶啶衍生物BIBW-22可以逆转人类恶性肿瘤细胞的多药抗性,该化合物可与P-糖蛋白(P-gp)结合,但无钙通道阻断作用。本文观察了BIBW-22对恶性疟原虫氯喹抗
A pteridin derivative, BIBW-22, reverses multidrug resistance in human malignant tumor cells. The compound binds to P-glycoprotein (P-gp) without blocking calcium channels. This article investigates the efficacy of BIBW-22 on Plasmodium falciparum chloroquine resistance