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目的:探讨门诊运用苦参素对耐拉米夫定乙型肝炎患者安全停药的临床效果。方法:对17例门诊就诊的耐拉米夫定乙型肝炎患者,口服苦参素600 mg/d,拉米夫定有计划停药,通过检测有计划停药过程中的肝功能、血清转换和HBV-DNA载量进行分析。结果:17例患者均安全停药,肝功能恢复并维持正常,HBV-DNA滴度下降。结论:长期苦参素治疗可使拉米夫定耐药病例安全停药,并有护肝和抗乙肝病毒效果。
Objective: To investigate the clinical effect of oxytocin on the safe withdrawal of hepatitis B patients receiving lamivudine. Methods: Seventeen outpatients with resistance to hepatitis B in resistance to lamivudine were given orally with oxymatrine 600 mg / d. Lamivudine was discontinued in a planned manner. By testing for liver function during planned withdrawal, seroconversion And HBV-DNA load were analyzed. Results: All the 17 patients were safely stopped, the liver function recovered and remained normal, and the HBV-DNA titer decreased. Conclusion: Long-term oxymatrine treatment can safely stop lamivudine-resistant cases and protect liver and anti-hepatitis B virus.