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目的:对老年恶性肿瘤患者的甲状腺功能状态及化疗对其甲状腺功能的影响进行探讨。方法:将我院38例老年恶性肿瘤患者纳入研究对象,再以同期进行健康检查的38例患者进行比较,分别命名为观察组和参照组,对比两组老年人的甲状腺功能,并对观察组进行化疗,观察其甲状腺功能的变化。结果:与健康者相比,观察组患者的甲状腺激素和促甲状腺素水平无明显差异,P>0.05;化疗后观察组患者的游离三碘甲状腺原氨酸较化疗前有明显差异,P<0.05。结论:和健康人群相比,恶性肿瘤老年人群的甲状腺激素和促甲状腺激素没有较大差异,但肿瘤患者在接受化疗治疗后,其甲状腺功能减退和亚临床性甲减的发生率会增加,所以化疗药物对老年恶性肿瘤患者的甲状腺功能有一定的影响。
Objective: To investigate the thyroid function in elderly patients with malignant tumor and the effect of chemotherapy on thyroid function. Methods: Thirty-eight elderly patients with malignant tumors in our hospital were enrolled in the study. Thirty-eight patients were selected as the observation group and the reference group respectively. The thyroid function was compared between the two groups. The observation group Chemotherapy to observe changes in thyroid function. Results: There was no significant difference in thyroid hormones and thyroxine between the observation group and the healthy group (P> 0.05). After treatment, the free triiodothyronine in the observation group was significantly lower than that before chemotherapy (P <0.05) . CONCLUSIONS: There is no significant difference between thyroid hormone and thyrotropin in elderly patients with malignancy compared to healthy people, but the incidence of hypothyroidism and subclinical hypothyroidism increases after cancer patients receive chemotherapy Chemotherapy drugs have a certain impact on thyroid function in elderly patients with malignant tumors.