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目的探讨染色体随体区变异在不良孕产中的可能作用。方法对2009年8月~2013年10月来我院就诊的生殖异常患者,取外周血淋巴细胞培养,并经G显带、C显带及染色体图象分析仪分析。结果在对3696例患者中,检出62例随体区变异(占1.7%),其中随体增加(ps+)28例,占随体区变异的45.1%;双随体(pss)12例,占随体区变异的19.3%;随体柄增加(pstk+)6例,占随体区变异的9.8%;随体区异染色质增加(ph+)4例,占随体区变异的6.5%;随体缺失(ps-)10例,占随体区变异的16.1%;Y染色体长臂上的随体(Yqs)2例,占随体区变异的3.2%。结论在不良孕产患者中应高度关注染色体随体区变异。
Objective To investigate the possible role of chromosomal aberrations in non-pregnant motherhood. Methods Reproductive abnormalities in our hospital from August 2009 to October 2013 were cultured in peripheral blood lymphocytes and analyzed by G-banding, C-banding and chromosome image analyzer. Results Of the 3696 patients, 62 cases were detected with the variation of the size of the body region (accounting for 1.7%), of which 28 (ps +) with the body size accounted for 45.1% Accounting for 19.3% of the variation in the region; 6 cases (pstk +) increased with the body stem, accounting for 9.8% of the variation in the region; 4 cases of ph + There were 10 cases with ps- (ps-), accounting for 16.1% of the variation of the body-region. There were 2 cases of Yqs on the long arm of Y chromosome, accounting for 3.2% of the variation in the body region. Conclusion In patients with adverse pregnancy should pay great attention to chromosomal variation with the body area.