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摘要目的分析MR氧代谢和新生血管特征生理成像对胶质瘤进行分级及探查IDH(异柠檬酸脱氢酶)基因突变的诊断效能。材料与方法本回顾性研究经机构伦理委员会批准,所有病人均签署知情同意书。83例经病理证实的脑胶质瘤(WHOⅡ~Ⅳ级)进行MR定量血氧水平依赖成像和血管结构成像。计算新生血管形成活性的生物标志物[微血管半径、微血管密度和微血管类型指标(MTI)]和氧代谢[氧摄
Abstract Objective To analyze the classification of glioma by MR oxygen metabolism and neovascularization physiological imaging and explore the diagnostic efficacy of IDH (isocitrate dehydrogenase) gene mutation. Materials and Methods This retrospective study was approved by the Institutional Ethics Committee and all patients signed informed consent. 83 cases of pathologically confirmed glioma (WHO Ⅱ ~ Ⅳ grade) for MR quantitative blood oxygenation-dependent imaging and vascular structure imaging. Biomarkers were calculated for neovascularization activity [microvascular radius, microvessel density and microvascular type index (MTI)] and oxygen metabolism [oxygenation