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目的:明确普米克令舒联合沙丁胺醇雾化吸入在治疗北方地区常见的四种喘息性疾病包括支气管哮喘、毛细支气管炎、喘息性支气管炎及喘型支气管肺炎中的疗效。方法:388名喘息性疾病患儿随机分为两组,试验组200例,治疗上给予常规治疗并加用普米克令舒联合沙丁胺醇雾化吸入;对照组188例,治疗上给予传统的常规治疗。结果:①用药20min后肺部喘鸣音消失情况:试验组与对照组比较,试验组疗效优于对照组,喘鸣音消失迅速(χ2=33.43,P<0.05);②3天后综合疗效判定:应用秩和检验,试验组与对照组相比差异有显著性,试验组疗效优于对照组(Uc=14.87,P<0.01)。结论:普米克令舒联合沙丁胺醇雾化吸入治疗上述四种喘息性疾病具有起效迅速,疗效确切,缩短疗程,不良反应少及易于接受的优点,适合于临床推广应用。
OBJECTIVE: To determine the efficacy of pulmicort respules combined with salbutamol inhalation in the treatment of four wheezing diseases common in the north including bronchial asthma, bronchiolitis, asthmatic bronchitis and asthmatic bronchopneumonia. Methods: 388 asthmatic children were randomly divided into two groups, the experimental group of 200 cases, the treatment of conventional treatment plus pulmicort / salbutamol inhalation; 188 cases of control group, the treatment of conventional conventional treatment . Results: (1) The disappearance of pulmonary wheeze after 20 minutes of treatment: Compared with the control group, the experimental group had better curative effect than the control group (P <0.05) The rank sum test showed that the difference between the experimental group and the control group was significant. The effect of the experimental group was better than that of the control group (Uc = 14.87, P <0.01). Conclusion: Pulmicort respules combined with salbutamol inhalation for the treatment of the four wheezing diseases mentioned above have the advantages of rapid onset, definite curative effect, short course of treatment, few adverse reactions and easy to accept, which are suitable for clinical popularization and application.