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探讨ABO血型不合的异基因造血干细胞移植 (Allo -HSCT)的造血问题。方法 :对 2例患者分别进行异基因外周血造血干细胞移植 (Allo -PBSCT)及脐血造血干细胞移植 (CBSCT) ,用血细胞分离机或 6 %羟乙基淀粉去除移植物中的红细胞 ,定期检测受者血型 ,根据情况输注血细胞。结果 :2例患者全部获得造血重建 ,未出现溶血反应。结论 :ABO血型不合可以进行Allo -HSCT ,去除供者移植物中的红细胞能有效地防止急性溶血反应的发生 ,定期检测受者血型 ,及时调整输血方案有重要的临床意义。
To investigate the hematopoietic problems of Allo-HSCT with ABO incompatible allogeneic hematopoietic stem cell transplantation. Methods: Allo-PBSCT and cord blood stem cell transplantation (CBSCT) were performed in 2 patients. The erythrocytes in the grafts were removed with a hemocytometer or 6% hydroxyethyl starch, Recipient blood type, according to the situation of transfusion of blood cells. Results: All of the 2 patients received hematopoietic reconstitution without hemolytic reaction. CONCLUSION: Allo-HSCT can be performed with ABO blood group incompatibility. Removal of erythrocytes from donor grafts can effectively prevent the occurrence of acute hemolytic reaction. It is of important clinical significance to detect the blood type of the recipient periodically and adjust the blood transfusion schedule.