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目的系统评价热毒宁注射液联合利巴韦林治疗小儿手足口病的临床疗效及安全性。方法计算机检索CNKI、VIP、Wan Fang Data、CBM等中文数据库以及Pubmed、The cochrane library、EMBase等英文数据库关于热毒宁联合利巴韦林治疗小儿手足口病的随机对照试验(各数据库检索时间均从建库-2015年9月)。对符合纳入和排除标准的文献进行提取数据及质量评价,采用RevMan 5.2软件进行Meta分析。结果最终纳入文献37篇,共6886例患者。Meta分析示热毒宁联合利巴韦林与单用利巴韦林相比:联合用药组总有效率更高[OR=4.30,95%CI(3.60,5.15),P<0.00001],患者的退热时间[MD=﹣1.61,95%CI(﹣1.79,﹣1.44),P<0.00001]、疱疹消退时间[MD=﹣2.44,95%CI(﹣3.05,﹣1.83),P<0.00001]、皮疹消退时间[MD=﹣1.65,95%CI(﹣1.89,﹣1.42),P<0.00001]、口腔溃疡消退时间[MD=﹣1.52,95%CI(﹣1.81,﹣1.22,)P<0.00001]、总疗程[MD=﹣2.18,95%CI(﹣2.70,﹣1.66),P<0.00001]均比单用利巴韦林更短,2组差异具有统计学差异。结论本研究结果示:热毒宁联合利巴韦林治疗小儿手足口病临床疗效优于单用利巴韦林。
Objective To evaluate the clinical efficacy and safety of Reverining Injection combined with ribavirin in the treatment of hand-foot-mouth disease in children. Methods A computer-controlled randomized controlled trial was conducted in Chinese databases such as CNKI, VIP, Wan Fang Data and CBM, and Pubmed, The Cochrane library, EMBase and other English databases on the treatment of HFMD combined with ribavirin in pediatric patients with HFMD From building a library - September 2015). Meta-analysis was performed using RevMan 5.2 software for data extraction and quality evaluation of articles that met inclusion and exclusion criteria. The results were finally included in the literature 37, a total of 6886 patients. Meta-analysis showed that the combination of retoxicating with ribavirin and ribavirin alone compared with the combination of the total effective rate was higher [OR = 4.30,95% CI (3.60,5.15), P <0.00001], the patient’s withdrawal P <0.00001], Herpes remission time [MD = -2.44, 95% CI (-3.05, -1.83), P <0.00001], rash time [MD = -1.61,95% CI -1.79 -1.44, The regression time [MD = -1.65,95% CI (-1.89, -1.42), P <0.00001], oral ulcer regression time [MD = -1.52,95% CI (-1.81, -1.22, P <0.00001] The total duration of treatment (MD = -2.18, 95% CI (-2.70, -1.66), P <0.00001] was shorter than that of ribavirin alone. The difference between the two groups was statistically significant. Conclusions The results of this study show that the combination of Reverining and Ribavirin is superior to Ribavirin in the treatment of HFMD in children.