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人们认为大量存在于污染的大气中的苯并茈(BAP)是引起人类癌症的动因,因此以各种化合物修饰改变Bap 在各种生物体系中的生物学、致突和致癌效应,特别是抑制其代谢,对预防Bap 对人类的危害似很重要。过去报告过氯化血红素及有关呲咯色素能抑制许多致癌物包括Bap 对微生物的诱变效应,然而微生物体系在很多方面都与哺乳类细胞有区别,本文则以中国地鼠VT9细胞为材料进行研究。V79细胞并不代谢Bap 等前致癌物,因此Bap 对V79不产生诱变效应,但当V79细胞与X 线辐射的地鼠胚细胞共同培养时,在Bap 存在下,则产生重要的突变。氯化血红素本身对细胞不具毒性也不致突,
It is believed that benzopyrene (BAP), which is abundant in the polluted atmosphere, is the cause of cancer in humans and therefore various biological modifications of the compounds alter the biological, mutagenic and oncogenic effects of Bap in various biological systems and in particular, inhibit Its metabolism, it is important to prevent the harm of Bap to humans. Past reports of hemin and related pyrrhetic pigments have been shown to inhibit the mutagenic effects of many carcinogens, including Bap, on microorganisms. However, microbial systems are differentiated from mammalian cells in many aspects. In this paper, we used Chinese hamster VT9 cells as materials research. V79 cells do not metabolize pro-carcinogens such as Bap, so Bap has no mutagenic effect on V79, but important mutations occur in the presence of Bap when V79 cells are co-cultured with x-ray hamster germ cells. Hemin itself is not toxic to the cells nor to sudden,