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用火焰原子吸收法测定Ⅱ型糖尿病（ＮＩＤＤＭ）２４例红细胞钙总量及用激光衍射法测定其红细胞变形性（ＲＣＤ）。测定５０例ＮＩＤＤＭ之红细胞在１５０、２００、２５０、３００及３５０ｍｍｏｌ／Ｌ５种渗透压悬液中的变形性。结果表明，正常成人红细胞钙总量为３３．６２±１２．８０μｍｏｌ／Ｌ，ＲＣＤ降低的ＮＩＤＤＭ患者，其红细胞钙总量明显升高（４６．３７±２３．３７μｍｏｌ／Ｌ，Ｐ＜０．０５），而ＲＣＤ正常之患者则接近正常水平。不同渗透压悬液中的最大ＤＩ值（ＤＩｍａｘ）显示，ＲＣＤ降低之ＮＩＤＤＭ红细胞在２５０及３００ｍｍｏｌ／Ｌ的ＤＩｍａｘ显著减小（Ｐ＜０．００１）；而在１５０及２００ｍｍｏｌ／Ｌ的低渗范围，其ＤＩｍａｘ接近正常，符合内粘度加大的ＤＩｍａｘ渗透压曲线特征。
Twenty - four patients with type Ⅱ diabetes mellitus (NIDDM) were recruited to determine the total amount of calcium in the erythrocytes by flame atomic absorption spectrometry. The erythrocyte deformability (RCD) was measured by laser diffraction. The deformability of 50 NIDDM red blood cells in 150, 200, 250, 300 and 350 mmol / L osmotic suspensions was measured. The results showed that the total amount of calcium in erythrocytes was significantly increased in patients with NIDDM with decreased RCD (33.62 ± 12.80μmol / L) (46.37 ± 23.37μmol / L, P <0.05 ), While patients with normal RCD are close to normal levels. The maximal DI value (DImax) in different osmotic pressure suspensions showed that the DImax of erythrocytes with reduced RCD decreased significantly at 250 and 300 mmol / L (P <0.001), while at 150 and 200 mmol / L , Its DImax close to normal, consistent with increased intraocular viscosity DImax osmotic pressure curve characteristics.