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目的分析膀胱灌注联合同期深部热疗对非肌层浸润性膀胱癌术后复发的临床效果。方法非肌层浸润性膀胱癌行经尿道膀胱肿瘤电切术病人98例,将98例病人随机分为研究组和对照组,每组各49例。对照组病人采用丝裂霉素膀胱灌注治疗,研究组在对照组基础上同期应用深部热疗。比较两组病人复发率及治疗期间不良反应发生情况。结果研究组6个月、9个月、12个月、15个月、18个月复发率分别为4.08%、6.12%、10.20%、10.20%和14.29%,对照组分别为10.20%、12.24%、18.37%、20.41%和24.50%。两组比较差异有统计学意义(P<0.05)。两组病人膀胱刺激症状、血尿、尿道狭窄、泌尿系感染发生率比较差异无统计学意义(P>0.05)。结论膀胱灌注联合同期深部热疗可降低非肌层浸润性膀胱癌术后复发率,且不会增加治疗本身所产生的不良反应。
Objective To analyze the clinical effects of intravesical instillation combined with deep hyperthermia on the recurrence of non-muscle invasive bladder cancer. Methods A total of 98 patients with non-muscle invasive bladder cancer undergoing transurethral resection of the bladder tumor were enrolled. 98 patients were randomly divided into study group and control group, with 49 cases in each group. Control group patients treated with mitomycin bladder irrigation, the study group in the control group based on the same period of deep hyperthermia. The recurrence rate of two groups were compared and the incidence of adverse reactions during treatment was compared. Results The recurrence rates of the study group were 4.08%, 6.12%, 10.20%, 10.20% and 14.29% at 6 months, 9 months, 12 months, 15 months and 18 months respectively, while those in the control group were 10.20% and 12.24% , 18.37%, 20.41% and 24.50% respectively. The difference between the two groups was statistically significant (P <0.05). There was no significant difference in the incidence of bladder irritation, hematuria, urethral stricture and urinary infection between the two groups (P> 0.05). Conclusions Bladder perfusion combined with deep hyperthermia during the same period can reduce the recurrence rate of non-muscle invasive bladder cancer without increasing the adverse reactions caused by the treatment itself.