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目的 :观察赛庚啶对小鼠脑缺血后学习记忆行为的影响。方法 :用昆明系小鼠夹闭双侧颈总动脉 ,脑缺血 15min后复灌模型 ,按组分别静脉注射赛庚啶 2mg·kg-1·d-1,尼莫地平 2mg·kg-1·d-1及对照组生理盐水 10ml·kg-1.d-1。人工常规饲养一周后 ,检测开场行为、回避反应和水迷宫试验以观察小鼠学习记忆行为的改变。结果 :赛庚啶组首次检测结果与 2 4h后再次检测结果比较均有显著差异 ,而对照组则均无显著改变。结论 :结果表明该脑缺血复灌损伤可导致记忆障碍 ,赛庚啶对小鼠脑缺血后的记忆保持有较好的改善作用
Objective: To observe the effects of cyproheptadine on learning and memory in mice after cerebral ischemia. Methods: Bilateral common carotid arteries were occluded in Kunming mice and reperfusion after 15 min of cerebral ischemia. Cyclopine 2 mg · kg-1 · d-1 and nimodipine 2 mg · kg-1 · D-1 and control group saline 10ml · kg-1.d-1. One week after artificial routine feeding, the opening behavior was detected, evasion reaction and water maze test to observe the changes of learning and memory behavior in mice. Results: The results of the first test in the cyproheptadine group were significantly different from the results of the second test after 24 hours, but not in the control group. CONCLUSIONS: The results show that this cerebral ischemia-reperfusion injury can lead to memory impairment, and cyproheptadine has a better effect on memory retention in mice after cerebral ischemia