草酸铂是第3代铂类抗癌药物,与顺铂或卡铂不同之处在于它包含1个环状大基团(1,2-二氨基环己烷),草酸铂-DNA复合物一旦形成,对DNA修复有更大的抵抗力,能更有效的抑制DNA复制。在临床前和临床研究中,草酸铂对许多不同类型的肿瘤都显示出抗瘤活性,尤其对顺铂和卡铂耐药的结直肠癌? Oxaliplatin is a 3rd generation platinum anticancer drug that differs from cisplatin or carboplatin in that it contains one large cyclic group (1,2-diaminocyclohexane), and once the oxalate-DNA complex has been formed Formation, greater resistance to DNA repair, can more effectively inhibit DNA replication. In preclinical and clinical studies, oxaliplatin shows antitumor activity in many different types of tumors, especially in cisplatin and carboplatin-resistant colorectal cancers.