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检测了各期血吸虫病患者外周血单个核细胞体外诱生IL-2的水平、T细胞亚群和抑制性T细胞(Ts)功能。急性组由血吸虫抗原诱生出高水平的IL-2,CD_3~+、CD_4~+和CD_8~+T细胞百分比均显著升高,其中IL-2水平与CD_4~+T细胞百分比呈正相关;慢性和晚期组由血吸虫抗原诱生的IL-2水平显著低于急性组,但明显比对照组高,CD_3~+T细胞百分比和CD_4~+/CD_8~+比值降低,CD_8~+T细胞百分比和Ts功能升高,IL-2水平与CD_8~+T细胞百分比和Ts功能呈负相关,其中晚期组由PHA诱生的IL-2水平明显降低。
The levels of IL-2, T lymphocyte subsets and inhibitory T cells (Ts) in peripheral blood mononuclear cells were detected in patients with schistosomiasis in different stages. The percentage of IL-2, CD_3 ~ +, CD_4 ~ + and CD_8 ~ + T cells induced by schistosome antigen was significantly increased in acute group, and the level of IL-2 was positively correlated with the percentage of CD_4 ~ + T cells. The levels of IL-2 induced by schistosome antigen in the late stage were significantly lower than those in the acute group, but significantly higher than those in the control group. The percentage of CD_3 ~ + T cells and the ratio of CD_4 ~ + / CD_8 ~ +, CD_8 ~ + T cells and Ts There was a negative correlation between the level of IL-2 and the percentage of CD8 + T cells and the function of Ts, and the levels of IL-2 induced by PHA in the latter group were significantly decreased.