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目的通过铅中毒小鼠口服火龙果观察火龙果是否具有排铅作用。方法选用18~22 g SPF雌性昆明种小鼠50只,随机分成阴性对照组、模型对照组和高、中、低剂量火龙果受试物组共5组,每组10只。采用自由饮用醋酸铅水溶液建立铅中毒小鼠实验模型,连续灌胃给药45d。摘眼球采集血液,断颈处死动物,取肝脏、骨骼用原子吸收法测定铅含量。结果火龙果可增加铅中毒小鼠铅的排出量,降低血液、骨骼和肝脏中的铅含量,结果提示火龙果对铅中毒小鼠有促进排铅作用。结论火龙果的排铅效果是由火龙果所含的营养成分(维生素、果胶、鞣酸、微量元素等)与铅作用的结果。
Objective To observe whether dragon fruit possesses lead excretion by oral administration of dragon fruit in mice with lead poisoning. Methods Fifty female Kunming mice of 18-22 g SPF were randomly divided into negative control group, model control group and high, medium and low doses of dragon fruit test group, a total of 5 groups of 10 rats. A model of lead poisoning mice was established by drinking free lead acetate aqueous solution and administered orally for 45 days. Blood was taken from the eyeball, animals were sacrificed by cervical dislocation, and the liver and bone were taken for determination of lead by atomic absorption spectrometry. Result Pitaya increased lead excretion in lead-poisoned mice and decreased lead in blood, bone and liver. The results suggest that pitaya promotes lead excretion in lead-poisoned mice. Conclusion The lead-discharging effect of dragon fruit is the result of the action of lead (pectin, tannic acid, trace elements, etc.) contained in dragon fruit.