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[目的]探讨慢性苯中毒患者T淋巴细胞亚群变化及接苯作业工龄对其的影响。[方法]2008年,在济南医院门诊、病房选取68例慢性苯中毒(轻度中毒25例、中度中毒15例、重度中毒28例)患者和20名正常对照者,应用流式细胞仪检测的外周血T淋巴细胞亚群。[结果]轻、中、重度慢性苯中毒患者的红细胞计数、白细胞计数、血红蛋白值、血小板计数、中性粒细胞均低于正常对照组(P<0.01)。轻度、中度、重度慢性苯中毒者,CD4+值和CD4+/CD8+值,均为接苯工龄5～30年的低于<5年的(P<0.01)。[结论]苯作业工龄越长的慢性苯中毒患者细胞免疫功能的损伤程度越严重。
[Objective] To investigate the changes of T lymphocyte subsets in patients with chronic benzene poisoning and the influence of the length of service on the exposure to benzene. [Methods] In 2008, 68 cases of chronic benzene poisoning (mild poisoning in 25 cases, moderate poisoning in 15 cases and severe poisoning in 28 cases) and 20 normal controls were selected in the outpatient and ward of Jinan Hospital. Flow cytometry Of peripheral blood T lymphocyte subsets. [Results] The counts of red blood cells, white blood cell count, hemoglobin, platelet count and neutrophils in mild, moderate and severe chronic benzene poisoning patients were lower than those in normal control group (P <0.01). Mild, moderate and severe chronic benzene poisoning, CD4 + values and CD4 + / CD8 + values were below 5 years (P <0.01) of 5-30 years of benzene treatment. [Conclusion] The longer the length of benzene in chronic benzene poisoning patients, the more serious cellular immune function damage.