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目的探讨血清降钙素原(PCT)在慢性阻塞性肺疾病急性加重期(AECOPD)抗菌治疗中的指导作用。方法收集105例AECOPD患者,分为PCT组(57例)和对照组(48例),观察两组7 d临床有效率、抗生素使用率、平均抗生素疗程、人均抗生素费用、总住院费用、住院天数、半年内复发(仅指住院)次数和半年内死亡例数(病死率)。结果两组抗生素使用率、平均抗生素疗程、人均抗生素费用、住院天数和总住院费差异均有统计学意义(均<0.05);两组在治疗后7 d临床有效率、半年内复发次数及病死率差异均无统计学意义(均>0.05)。结论血清PCT在指导AECOPD抗感染治疗情况下能够有效减少抗生素使用率、平均抗生素疗程、人均抗生素费用及住院总费用,并缩短患者的住院时间,且没有影响近期和远期疗效。
Objective To investigate the role of serum procalcitonin (PCT) in the antimicrobial therapy of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 105 patients with AECOPD were enrolled in this study. The patients were divided into the PCT group (57 cases) and the control group (48 cases). The clinical effective rate, the antibiotic utilization rate, the average antibiotic treatment, the average antibiotic expense, the total hospitalization expense, , Recurrence within six months (only referred to hospital) and the number of deaths within six months (mortality). Results The two groups had statistically significant differences in the rate of antibiotic use, the mean duration of antibiotic treatment, the average cost of antibiotics per day, the number of days of hospitalization and the total cost of hospitalization (all <0.05) There was no significant difference in rates (all> 0.05). Conclusions Serum PCT can effectively reduce the antibiotic usage, mean duration of antibiotic treatment, per capita antibiotic expense and total cost of hospitalization, and shorten the hospitalization time of patients under the guidance of AECOPD anti-infective treatment, without affecting the short-term and long-term effects.