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目的分析检测降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平在脓毒血症中的诊断价值及意义。方法选取医院明确诊断脓毒血症患者90例(脓毒血症组)、普通体检志愿者90例(对照组)作为研究对象。采取脓毒血症组患者(未使用抗菌药物且发热高峰期)及志愿者当天体检血样,送血培养分别采用电化学发光法测定PCT、IL-6水平,免疫透射比浊法测定CRP水平。结果脓毒血症组PCT、CRP、IL-6检测值均明显高于健康对照组(P<0.01);PCT诊断脓毒血症时的灵敏度、特异性、准确度、阳性预测值均高于CRP和IL-6,3项联合检测的诊断价值均高于单独检测,差异有统计学意义(P<0.05)。结论 PCT、CRP、IL-6均有助于临床识别脓毒症,3项联合检测可提高快速确诊脓毒血症的准确度,可进一步于临床推广应用。
Objective To analyze the diagnostic value and significance of detecting the levels of procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in sepsis. Methods Ninety patients (sepsis group) with definite diagnosis of sepsis in hospital and 90 volunteers (normal control group) were selected as research subjects. The levels of PCT and IL-6 were determined by electrochemiluminescence assay and CRP levels by immunoturbidimetry in patients with sepsis (no antimicrobial agents and peak fever) and blood test and blood culture in volunteers. Results The serum PCT, CRP and IL-6 levels in sepsis group were significantly higher than those in healthy control group (P <0.01). The sensitivity, specificity, accuracy and positive predictive value of PCT in sepsis were higher than The diagnostic value of combined detection of CRP and IL-6 and 3 were higher than that of single test, the difference was statistically significant (P <0.05). Conclusions PCT, CRP and IL-6 all contribute to the clinical identification of sepsis. The three combined tests can improve the accuracy of rapid diagnosis of sepsis and further promote the clinical application.