调查显示,目前临床使用频率较高的抗精神病药依次是氯氮平、利培酮、舒必利、氯丙嗪,治疗过程中由于药源性及并发症等各种原因常合并使用其他药物,最常合并使用的药物是抗胆碱能药、苯二氮革类药、β-受体阻断药、抗抑郁药和心境稳定药。鉴于抗精神病药与肝脏细胞色素P450(CYP450)酶系关系密切,容易与多种药物产生具有临床意义的药物相 Surveys show that at present the higher frequency of clinical use of antipsychotics followed by clozapine, risperidone, sulpiride, chlorpromazine, due to drug-induced complications and other causes often combined with the use of other drugs, the most Commonly used drugs are anticholinergics, benzodiazepines, beta-blockers, antidepressants and mood stabilizers. In view of antipsychotics and liver cytochrome P450 (CYP450) enzymes are closely linked with a variety of drugs and easy to produce clinically meaningful drug phase