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检测正常人６５例，９１例消化道癌均经Ｘ线造影及内镜活检病理确诊，４６例原发性肝癌经Ｂ超、ＣＴ定位及穿刺活检病理证实，并排除转移癌可能。五项指标在不同病种各有不同程度升高．与正常人对比，有显著差别（Ｐ＜０．０５），其中４６例原发性肝癌ＡＦＰ、ＳＦ差别非常显著（Ｐ＜０．０１）。在五项指标中，ＡＦＰ仍为原发性肝癌的主要诊断指标，其诊断效能高于其它指标。ＳＦ诊断效能仅次于ＡＦＰ优于其它３项。ＡＦＰ、ＳＦ两项指标组合，灵敏性为８６．９５％，特异性为９５．６８％，正确诊断率为９７．８２％。我们认为，对ＡＦＰ低浓度不典型病例，应结合临床影像学检查，对放免肿瘤标志物作动态观察，有利于及时正确诊断。
Sixty-five normal persons were detected. 91 cases of digestive tract cancer were confirmed by X-ray angiography and endoscopic biopsy. 46 cases of primary liver cancer were confirmed by B-ultrasonography, CT localization, and pathological biopsy, and the possibility of metastasis was excluded. The five indicators have increased in different degrees in different diseases. Compared with normal subjects, there was a significant difference (P<0.05), of which 46 cases of primary liver cancer AFP, SF difference is very significant (P<0.01). Among the five indicators, AFP is still the main diagnostic indicator of primary liver cancer, and its diagnostic efficiency is higher than other indicators. The SF diagnostic performance is second to AFP superior to the other three. The combination of AFP and SF indexes has a sensitivity of 86.95%, a specificity of 95.68%, and a correct diagnosis rate of 97.82%. We believe that in the case of atypical low-density AFP cases, clinical imaging studies should be combined with dynamic observation of radioimmunity markers to facilitate timely and correct diagnosis.