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有机氰化物是一种重要的合成中间体,在药物、农药、染料和活性物质中都有应用.使用廉价、简单、低毒的氰基化合物在过渡金属的催化下通过C—CN键断裂生成复杂的氰化物是合成有机氰化物的重要手段之一.综述了不同过渡金属(如Ni,Pd,Rh,Cu,Ru,Fe,Mo,Co等)催化不同种类的氰基化合物C—CN键断裂的最新研究进展,如含C(sp1)—CN键化合物、C(sp2)—CN键化合物以及C(sp3)—CN键化合物,并对有关的反应机理及C—CN键断裂机理的进展进行了探讨.
Organic cyanide is an important synthetic intermediate used in pharmaceuticals, pesticides, dyes and active substances. The use of cheap, simple, low toxicity cyano compounds catalyzed by transition metal through the C-CN bond rupture Complex cyanide is one of the most important ways to synthesize organic cyanide compounds. It is reviewed that different transition metals such as Ni, Pd, Rh, Cu, Ru, Fe, Mo and Co catalyze C-CN bonds The latest research progress of fracture, such as C (sp1) -CN bond, C (sp2) -CN bond and C (sp3) -CN bond, and the related reaction mechanism and the progress of C-CN bond fracture mechanism Discussed.