论文部分内容阅读
目的研究B淋巴细胞激活因子与儿童特发性血小板减少性紫癜(ITP)的相关性。方法选择特发性血小板减少性紫癜患儿作为观察组,给予免疫抑制剂治疗1周,同期体检的健康儿童作为对照组,采用酶联免疫法检测外周血中BAFF,PAIgG,PAIgM,PAIgA和PLT指标。结果治疗前,观察组中急性型和慢性型患者外周血BAFF,PAIgG,PAIgM,PAIgA均明显高于对照组,PLT计数明显少于对照组(P<0.05);治疗后,两组外周血BAFF,PAIgG,PAIgM,PAIgA指标比较差异无统计学意义(P>0.05)。结论BAFF的过度表达诱导自身抗体PAIg的产生与ITP的发生关系密切。
Objective To study the correlation between B lymphocyte activation factor and idiopathic thrombocytopenic purpura (ITP) in children. Methods Children with idiopathic thrombocytopenic purpura were selected as the observation group. Immunosuppressive agents were given for one week. Healthy children in the same period were taken as control group. The levels of BAFF, PAIgG, PAIgM, PAIgA and PLT in peripheral blood were detected by enzyme-linked immunosorbent assay index. Results Before treatment, the levels of BAFF, PAIgG, PAIgM and PAIgA in acute and chronic type of patients in observation group were significantly higher than those in control group, and the PLT count was significantly less than that in control group (P <0.05). After treatment, BAFF , PAIgG, PAIgM, PAIgA index was no significant difference (P> 0.05). Conclusion The over-expression of BAFF induces the production of PAIg, which is closely related to the occurrence of ITP.