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目的探讨子宫腺瘤样瘤(AT)的临床病理特征、诊断与鉴别诊断。方法回顾性分析22例子宫AT的临床病理学资料并进行特殊染色和免疫组化标记。结果 22例子宫AT占同期子宫切除标本1323例的1.7%,肿瘤多位于子宫肌壁间。肿瘤直径0.6~4 cm,临床表现无特征性。肿瘤由形态不一的腺样或腔隙样结构组成,腔隙内衬扁平或立方上皮细胞,间质伴有平滑肌组织增生。肿瘤细胞calretinin、HBME-1和CK(+),CEA、EMA和CD34(-)。结论子宫AT是一种比较少见的良性肿瘤,起源于浆膜间皮,应用免疫组化技术可有效提高子宫AT诊断的正确性,有重要的病理诊断价值。
Objective To investigate the clinical and pathological features, diagnosis and differential diagnosis of adenomatoid adenoma (AT). Methods A retrospective analysis of 22 cases of uterine atherosclerotic clinicopathological data and special staining and immunohistochemical markers. Results 22 cases of uterine AT accounted for 1.7% of 1,323 cases of hysterectomy in the same period, the tumor mostly located in the uterine muscle wall. Tumor diameter 0.6 ~ 4 cm, no clinical manifestations. The tumor is composed of adenoids or lacunar structures with different shapes, the lacuna is lined with flat or cubic epithelial cells, and the stroma is associated with smooth muscle tissue hyperplasia. Tumor cells calretinin, HBME-1 and CK (+), CEA, EMA and CD34 (-). Conclusion Uterine AT is a relatively rare benign tumor, which originated from serosal mesothelioma. The application of immunohistochemistry can improve the correctness of AT diagnosis in uterus and has important pathological diagnosis value.