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目前,恶性睾丸生殖细胞瘤的诊断主要依赖于肿瘤细胞的形态学特征,以及肿瘤的组织学检查.本文报导5种肿瘤标记物对睾丸生殖细胞瘤的诊断和分期的意义.这五种标记物是血清中的甲胎蛋白(AFP)、癌胚抗原(CEA)、人绒毛膜促性腺激素(HCG),人胎盘催乳素(HPL)以及妊娠特异的β_1-糖蛋白(SP_1).作者用特异的放射免疫法测定了111例睾丸生殖细胞瘤患者血清中这5种标记物.结果发现精母细胞瘤、成熟畸胎瘤、“纯型”的胚胎性癌以及含有精
At present, the diagnosis of malignant testicular germ cell tumors mainly depends on the morphological characteristics of tumor cells and the histological examination of tumors. This article reports the significance of five tumor markers for the diagnosis and staging of testicular germ cell tumors. Serum alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), human chorionic gonadotropin (HCG), human placental prolactin (HPL), and pregnancy-specific β 1 -glycoprotein (SP_1). The radioimmunoassay measured the serum levels of these 5 markers in 111 cases of testicular germ cell tumor patients. The results showed that spermatoblastoma, mature teratoma, “plain” embryonal carcinoma and containing sperm