Objective:To evaluate the effect of preoperative chemotherapy on locally advanced cervical cancer by internal iliac arterial infusion.Methods:Sixty two patients with bulky or locally advanced cervical cancer from 1999 to 2004 were underwent internal iliac arte- rial infusion chemotherapy by using Seldinger technique.Combined regimens were applied in- cluding cisplatin as the major drug.Two weeks later,all patients received radical hysterectomy. Results:The local tumor regression rate was 93.55%.Postoperative pathologic examination showed that no cervical tumor residue in stumps were found in 61 of 62 patients who underwent radical hysterectomy.Large quantity of necrotic tissue appeared on primary tumor.In 16 patients with positive lymph nodes,15 demonstrated necrotic lymph nodes.Conclusion:Internal iliac ar- terial infusion chemotherapy could effectively reduce tumor volume,increase surgical success rate and decrease lymph nodes and subclinical metastasis rates. Objective: To evaluate the effect of preoperative chemotherapy on locally advanced cervical cancer by internal iliac arterial infusion. Methods: Sixty two patients with bulky or locally advanced cervical cancer from 1999 to 2004 were underwent internal iliac arte rial infusion chemotherapy by using Seldinger technique. Combined regimens were applied in- cluding cisplatin as the major drug. Two weeks later, all patients received radical hysterectomy. Results: The local tumor regression rate was 93.55%. Postoperative pathologic examination showed that no cervical tumor residues in stumps were found in 61 of 62 patients who underwent radical hysterectomy. Large quantity of necrotic tissue was on primary tumor. In 16 patients with positive lymph nodes, 15 demonstrated necrotic lymph nodes. Confocal: Internal iliac ar- terial infusion chemotherapy could effectively reduce tumor volume, increase surgical success rate and decrease lymph nodes and subclinical metastasis rates.