论文部分内容阅读
目的探讨染色体多态性与女性习惯性流产的关系。方法对2012年1月以来在本院妇产科就诊的486例习惯性流产的女性遗传咨询者行外周血染色体核型分析。结果在486遗传咨询者中检出染色体多态性核型46占9.47%,根据多态性变异可主要归为下列3种类型:(1)D/G组随体增加共12例,占多态性的26.09%;(2)次缢痕增加(包括1号、9号、16号染色体)共10例,占多态性的21.74%;(3)9号染色体臂间倒位共24例,占多态性的52.17%。习惯性流产女性的染色体多态性的检出率显著高于健康对照组,差异有统计学意义(P<0.01)。习惯性流产组和对照组中最常见的多态性类型均为inv(9),分别为24例(4.94%)例和11例(1.44%),差异有统计学意义(P<0.01)。习惯性流产组的D/G组随体增加和次缢痕增加检出率也明显高于对照组,差异有统计学意义(P<0.01)。结论染色体多态性与女性习惯性流产发病有密切关系,对有习惯性流产病史的女性应进行外周血染色体检查。
Objective To explore the relationship between chromosome polymorphism and female habitual abortion. Methods Peripheral blood karyotype analysis was performed on 486 female genetic counselors who were admitted to obstetrics and gynecology department in our hospital since January 2012. Results 488 genetic counselors detected chromosome polymorphism 46 accounted for 9.47%, according to the polymorphism can be divided into the following three types: (1) D / G group with a total of 12 cases of increase, accounting for (2) the number of secondary marks increased (including chromosomes 1, 9 and 16) in 10 cases, accounting for 21.74% of the total; (3) A total of 24 cases Accounting for 52.17% of the total. The detection rate of chromosome polymorphism in habitual abortion women was significantly higher than that in healthy controls (P <0.01). The most common types of polymorphisms in habitual abortion group and control group were inv (9), which were 24 cases (4.94%) and 11 cases (1.44%), respectively. The difference was statistically significant (P <0.01). The detection rate of attending abortion group in D / G group was significantly higher than that in control group (P <0.01). Conclusion Chromosomal polymorphism is closely related to the incidence of female habitual abortion. Chromosome examination of peripheral blood should be performed on women with a history of habitual abortion.