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对周慧玲、相伶琴二位医师在本刊1980年4期发表的《小儿有机磷农药中毒50例临床分析》一文有几点不同看法,现提出商榷。一、1059、1605、乐果、3911等硫代磷酸酯类有机磷农药均不得使用1:5000高锰酸钾溶液洗胃。因为这些毒物在体外抑制胆硷酯酶的作用很弱,需在体内其结构中的硫(s)以氧(o)置换后转为磷酸键,方能发挥强大的抑制胆硷酯酶的作用。高锰酸钾可加速这一过程的进行,使之氧化成相应的氧化物,使其毒性增加
To Zhou Huiling, Xiang Lingqin two physicians published in the 1980 issue of “clinical analysis of 50 cases of organophosphorus pesticide poisoning in children,” a few different views, are now debated. A, 1059,1605, dimethoate, 3911 and other phosphorothioate organophosphorus pesticides are not allowed to use 1: 5000 potassium permanganate solution gastric lavage. Because these toxins inhibit the activity of cholinesterase in vitro to a very low extent, the sulfur (s) in the structure of the body needs to be replaced by oxygen (o) and then converted into a phosphate bond to exert a strong inhibitory effect on cholinesterase . Potassium permanganate accelerates the process, allowing it to oxidize to the corresponding oxide, increasing its toxicity