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GATA家族包含6个转录因子,其中每个转录因子都含有1个由锌指结构构成的高度保守的DNA结合域。根据表达模式和功能将这6个转录因子分为2组,其中GATA4主要在内胚层或中胚层来源的组织或器官中表达,GATA4,5,6对组织特异性基因的表达起关键性的调控作用。GATA4是心脏发育的重要调节因子,Grepin等发现在胚胎癌性细胞P19中GATA4的过表达会加速心肌细胞的分化,用反义链抑制GATA4的表达能抑制心肌细胞的分化并能引起细胞凋亡。也有相关研究表明GATA4,5,6除了调节组织特异性基因的表达,诱导特异性细
The GATA family contains six transcription factors, each of which contains a highly conserved DNA-binding domain composed of zinc finger structures. According to the expression pattern and function, these six transcription factors were divided into two groups. GATA4 was mainly expressed in endoderm or mesoderm-derived tissues or organs. GATA4,5,6 played a key role in the regulation of tissue-specific gene expression effect. GATA4 is an important regulator of heart development. Grepin et al. Found that overexpression of GATA4 in embryonic cancerous cells accelerated the differentiation of cardiomyocytes. Inhibition of GATA4 expression by antisense chain inhibited cardiomyocyte differentiation and induced apoptosis . There are also related studies have shown that GATA4,5,6 in addition to regulating the expression of tissue-specific genes, inducing specific thin