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利奈唑胺是时间依赖性抗生素,与临床疗效相关的药动学参数包括血药浓度高于最低抑菌浓度(MIC)的时间百分比(%T>MIC)和用药达稳态时24 h血药时曲线下面积与MIC的比值(AUC24/MIC)。一项回顾性研究结果显示,如果利奈唑胺血药浓度在整个给药间期均维持在MIC之上,或者AUC24/MIC为80至120,临床治疗成功率更高。但最近一些研究结果显示,部分患者利奈唑胺谷浓度低于利奈唑
Linezolid is a time-dependent antibiotic and the pharmacokinetic parameters associated with clinical efficacy include the percentage of time (% T> MIC) for plasma concentrations above the minimum inhibitory concentration (MIC) and 24 h for up to steady state The area under the curve versus MIC (AUC24 / MIC). A retrospective study showed that the clinical success rate was higher if linezolid plasma concentrations remained above the MIC for the entire dosing interval, or AUC24 / MIC was 80 to 120. However, some recent studies have shown that some patients with linezolid concentration lower than linezolid