羊膜最初在临床上用于皮肤烧伤患者的创面覆盖,1940年de Rotth[1]首次将新鲜胎膜(含羊膜和绒毛膜)应用于眼科进行结膜重建,但因含有抗原性很强的绒毛膜,移植片发生排斥溶解,而导致手术失败,为此使得羊膜应用停止了很长时间。1995年Ki m和Tseng[2]羊膜引入眼科领域,此后,广泛开 Amniotic membrane was first used clinically to cover wounds in patients with skin burns. In 1940 de Rotth [1] first applied fresh fetal membranes (including amniotic membrane and chorion) to ophthalmology for conjunctival reconstruction. However, due to the presence of antigenic chorionic , Transplant graft rejection occurs, which led to the failure of surgery, which makes the amniotic application stopped for a long time. 1995 Ki m and Tseng [2] amniotic membrane into the field of ophthalmology, since then, widely open