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为探讨乙醇及其代谢产物乙醛在胎儿酒精综合征 (FAS)中的作用 ,应用植入后全胚胎培养研究不同浓度的乙醇 ,乙醛组合对 9.5- 1 1 .5d大鼠胚胎发育的联合作用 .结果显示在卵黄囊直径 ,头长 ,体长 ,心脏 ,前脑 ,DNA含量等指标乙醇与乙醛存在交互作用 .进一步分析发现 0 .1 g·L-1乙醇与不同剂量乙醛组合可导致拮抗 ,协同和独立等多种联合作用类型 ,但对头长和脑均表现为独立作用 . 0 .2 g· L-1乙醇与不同剂量乙醛组合除心脏呈协同作用外其余均为乙醇独立作用 .上述结果提示 FAS中的脑发育异常是乙醇独立作用的结果 ,乙醛则引起FAS中的辅助畸形
In order to explore the role of ethanol and its metabolite acetaldehyde in fetal alcohol syndrome (FAS), the whole embryo culture after implantation was used to study the effects of different concentrations of ethanol and acetaldehyde on the development of embryonic development in 9.5-1.15d rats .The results showed that the interaction between alcohol and acetaldehyde existed in the indexes such as the diameter of yolk sac, head length, body length, heart, forebrain and DNA content.According to further analysis, the combination of 0.1 g · L -1 ethanol with different doses of acetaldehyde Can lead to antagonistic, synergistic and independent and other types of joint action, but the head length and brain showed an independent role .0.2 g · L-1 ethanol and different doses of acetaldehyde in addition to the synergistic combination of the heart of the rest are ethanol Independent effect.The above results suggest that brain dysplasia in FAS is the result of the independent effect of ethanol and acetaldehyde causes ancillary deformities in FAS