吡哌酸(pipemidic acid,PPA)是日本1975年化学合成的吡酮酸类抗菌药物,我国于1980年研制成功,并应用于临床。该药具有抗菌谱较广、口服易吸收、疗效肯定、毒副作用小等优点,近年应用日趋广泛。为了合理应用PPA,避免滥用,本文拟讨论以下问题。一、抗菌作用及体内过程 PPA对革兰氏阴性杆菌如大肠杆菌、痢疾杆菌、伤寒杆菌、变形杆菌(吲哚阳性及阴性)、产气杆菌、肺炎杆菌、沙雷氏菌等具有较强的抗菌活性,其中尤以大肠杆菌、痢疾杆菌、产气杆菌对它敏感。PPA Pipemidic acid (PPA) is Japan’s chemical synthesis of pyrazolonic acid antibacterial drugs in 1975, China was successfully developed in 1980, and used in clinical. The drug has broad antibacterial spectrum, oral absorption, efficacy is positive, the advantages of small side effects, in recent years, the increasingly widespread application. In order to apply PPA rationally and avoid abuse, this article discusses the following issues. First, the antibacterial effect and in vivo process PPA Gram-negative bacilli such as Escherichia coli, Shigella, Salmonella typhi, Proteus (indole positive and negative), Aerobacter aerogenes, Klebsiella pneumoniae, Serratia, etc. has a strong Antibacterial activity, especially Escherichia coli, Shigella, Aerobacter aureus sensitive to it. PPA