1865年,Trousseau首次报告肿瘤与血栓栓塞性疾病的关系,游走性静脉血栓形成首次被描述。而且,目前在肿瘤病人中,各种静脉和动脉其他的血栓栓塞性疾病被称为Trousseau′s综合征。尽管有争论,血栓栓塞现象一直被认为是潜隐性肿瘤,尤其是未有血栓形成的其他危险因素的癌症病人的先兆。血栓形成常可提示恶性肿瘤的诊断。 本文报告4例病人患有广泛的静脉血栓栓塞性疾病,随之诊断又患有恶性肿瘤。所有病人最后均应用enoxaparin(一种低分子肝素,low-Molecular-weight heparin,LMWH)皮下给药治疗,理想地控制了血栓栓塞。 In 1865, Trousseau first reported the relationship between tumors and thromboembolic disease, and for the first time, migratory venous thrombosis was described. Moreover, currently in vein tumors, other venous and arterial thromboembolic diseases are known as Trousseau’s syndrome. Despite the controversy, thromboembolism has always been considered as a latent tumor, especially in cancer patients without other risk factors for thrombosis. Thrombosis can often suggest a diagnosis of malignancy. This article reports that 4 patients suffered from extensive venous thromboembolic disease, followed by a diagnosis of malignancy. All patients were treated subcutaneously with enoxaparin (low-Molecular-weight heparin, LMWH), which ideally controlled thromboembolism.