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目的探讨双硫仑反应的临床表现及治疗,加强对双硫仑样反应的认识,掌握正确诊断和处理方法。方法回顾性分析本院急诊科2009-2012年间由于用药后饮酒导致的双硫仑样反应36例患者的临床资料。结果 36例患者中,35例在发病前都有应用抗生素(头孢为主)和饮酒病史,病情严重程度与用药剂量和饮酒量成正比,男性比例大。经及时治疗全部康复。结论预防双硫仑样反应的关键是医生宣教用药后2周内禁酒及接触含乙醇制品,治疗上详问病史急诊处置,对已有基础病的老年患者加强心电监测和综合护理。
Objective To investigate the clinical manifestation and treatment of disulfiram reaction, to strengthen understanding of disulfiram-like reaction and to master the correct diagnosis and treatment methods. Methods The clinical data of 36 patients with disulfiram-like reaction caused by alcohol consumption in our emergency department between 2009 and 2012 were retrospectively analyzed. Results Among the 36 patients, 35 patients had antibiotics (mainly cephalosporins) and a history of drinking before onset. The severity of the disease was proportional to the dose and alcohol consumption, with a large proportion of males. After timely treatment of all rehabilitation. Conclusions The key to preventing disulfiram-like reactions is to prohibit alcohol and alcohol-containing products within 2 weeks after the doctors declare medication. The medical history and emergency treatment should be treated in detail, and the ECG monitoring and comprehensive nursing should be strengthened for elderly patients with underlying diseases.