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目的探讨左氧氟沙星辅助抗结核药物治疗耐多药肺结核的临床疗效。方法选取2010年3月—2013年8月攀枝花市第四人民医院收治的耐多药肺结核患者140例,随机分为研究组与对照组,各70例。研究组患者予以左氧氟沙星辅助抗结核药物治疗,对照组患者予以常规抗结核药物治疗。观察两组患者治疗3、6、12个月及治疗后1个月痰菌转阴情况、影像学疗效(结核灶改善疗效、肺空洞改善疗效)及不良反应(胃肠道反应、肝功能轻度受损、肾功能轻度受损、头晕乏力)发生情况。结果研究组患者治疗3个月及治疗后1个月痰菌转阴率高于对照组,差异有统计学意义(P<0.05);两组患者治疗6、12个月痰菌转阴率比较,差异无统计学意义(P>0.05);研究组患者结核灶改善疗效和肺空洞改善疗效优于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论左氧氟沙星辅助抗结核药物治疗耐多药肺结核的临床疗效显著,可有效杀灭结核杆菌,且不良反应少。
Objective To investigate the clinical efficacy of levofloxacin-assisted anti-tuberculosis drugs in the treatment of multi-drug resistant pulmonary tuberculosis. Methods 140 cases of MDR-TB patients admitted to the Fourth People’s Hospital of Panzhihua from March 2010 to August 2013 were randomly divided into study group and control group, with 70 cases each. Patients in the study group were treated with levofloxacin-assisted anti-TB drugs, and patients in the control group were treated with conventional anti-TB drugs. The sputum negative conversion rate was observed at 3, 6, and 12 months after treatment and the sputum negative conversion rate was observed in two groups. The imaging efficacy (improvement of tuberculosis, efficacy of lung cavity improvement) and adverse reactions (gastrointestinal reaction, light liver function Degree of damage, mild impaired renal function, dizziness, fatigue) occurred. Results In the study group, the rate of sputum negative conversion rate was higher in the three months after treatment and one month after the treatment than in the control group (P <0.05). The negative conversion rate of sputum in the two groups was significantly lower than that in the control group , The difference was not statistically significant (P> 0.05); study group patients with tuberculosis to improve the efficacy and lung cavity improvement better than the control group, the difference was statistically significant (P <0.05); two groups of patients with adverse reactions, the difference No statistical significance (P> 0.05). Conclusion Levofloxacin adjuvant anti-tuberculosis drug treatment of multidrug-resistant pulmonary tuberculosis significant clinical efficacy, can effectively kill Mycobacterium tuberculosis, and less adverse reactions.