采用了一种改良的合成方法制备姜黄素,并确定了最优工艺条件。即:先将乙酰丙酮与硼酸酐于乙酸乙酯内回流反应30min,制得乙酰丙酮的硼络合物;然后在DMF(N,N-二甲基甲酰胺)中,将香兰素、三丁基硼酸酯及新制的乙酰丙酮的硼络合物于80℃,以正丁胺为催化剂反应3h;最后向其中加入5%的醋酸破坏络合物得到姜黄素粗品,以氯仿-甲醇重结晶得到姜黄素纯品。在投料量为百克级情况下,总收率达到了70%。这也为大量制备提供参考。 A modified synthesis method was used to prepare curcumin, and the optimum process conditions were determined. That is, firstly, acetylacetone and boric anhydride are refluxed in ethyl acetate for 30 min to prepare a boron complex of acetylacetone; then vanillin, tris (trimethylsilyl) amide Butyl boric acid ester and the new acetylacetone boron complex at 80 ℃ with n-butylamine as a catalyst for 3h; Finally, 5% acetic acid was added to destroy the complex to get the crude curcumin, with chloroform-methanol weight Crystallization of curcumin pure. The total yield of 70% is achieved when the dosage is 100g. This also provides a reference for mass preparation.