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目的：探讨金属硫蛋白（ＭＴ）对抗氧化酶的保护作用机制。方法：向大鼠尾静脉注射氯化镉建立镉中毒模型，分别于注射后不同时间测定肝组织ＭＴ的含量和抗氧化酶（ＳＯＤ，ＣＡＴ，ＧＳＨｐｘ）的活力变化。结果：镉中毒后３０ｍｉｎ～３ｈ，ＳＯＤ、ＧＳＨｐｘ和ＣＡＴ活力显著降低（Ｐ＜００５），６ｈ酶活力逐步恢复；ＭＴ的显著增加出现在３ｈ，６ｈ达最高峰（１３１９５±１５１５）μｇ／ｇ肝组织，随着ＭＴ的合成增加，抗氧化酶的活力逐步恢复。结论：镉中毒严重抑制抗氧化酶的活力，ＭＴ对抗氧化酶的活力恢复可能有良好的促进作用。
Objective: To explore the protective mechanism of metallothionein (MT) against oxidative enzymes. Methods: The model of cadmium poisoning was established by injecting cadmium chloride into the tail vein of rats. The content of MT and the activity of antioxidant enzymes (SOD, CAT, GSHpx) were measured at different time points after injection. Results: The activities of SOD, GSHpx and CAT decreased significantly (P <005) 30 min ~ 3 h after cadmium poisoning, and gradually recovered after 6 h. The MT increased significantly at 3 h and reached the peak at 6 h (13195 ± 15 15) μg / g liver tissue. As the synthesis of MT increased, the antioxidant enzyme activity gradually restored. Conclusion: Cadmium poisoning seriously inhibits the activity of antioxidant enzymes, MT may have a good role in promoting the recovery of antioxidant enzymes.