论文部分内容阅读
目的评价小剂量立加利仙治疗老年高尿酸血症患者的有效性和安全性。方法选择30例老年肾脏尿酸排泄减少的原发高尿酸患者作为研究对象,10例血尿酸正常的老年人作为基线对照。每日给予25 mg立加利仙,疗程一周。计算肌酐清除率(Ccr)、24 h尿尿酸(24h Uur)、尿酸清除率(Cur)、尿酸清除分数(FRUAC)、单位肾小球滤过率尿酸排出(EurGFCur)、尿尿酸与尿肌酐比值(Uur/Ucr)。结果治疗一周后,高尿酸患者平均Sur从8.48±1.52 mg/dl降低至4.98±1.53 mg/dl,24h Uur、Cur、FRUAC、EurGFCur、Uur/Ucr均显著增加(P<0.01),同时Ccr无明显变化,肾脏尿酸负荷(Flur)明显减少(P<0.001)。不同Ccr水平患者24h Uur增加百分数和Sur降低百分数无显著差异(P>0.05)。无不良反应发生。结论对轻度肾功能减退老年患者,立加利仙可促进尿酸排泄,显著降低血尿酸水平。短时间应用未见不良反应。
Objective To evaluate the efficacy and safety of low-dose telmisartan in the treatment of elderly patients with hyperuricemia. Methods Thirty elderly primary hyperuricemia patients with decreased uric acid excretion were enrolled in this study. Ten patients with normal serum uric acid were selected as the baseline controls. Give 25 mg Ligarene daily for one week. Ccr, 24h Uur, Cur, FRUAC, EurGFCur, urinary uric acid and urinary creatinine were calculated. (Uur / Ucr). Results After a week of treatment, the mean Sur of patients with hyperuricemia decreased from 8.48 ± 1.52 mg / dl to 4.98 ± 1.53 mg / dl, while the values of 24h Uur, Cur, FRUAC, EurGFCur and Uur / Ucr increased significantly (P <0.01) Significant changes, renal uric acid load (Flur) was significantly reduced (P <0.001). Patients with different levels of Ccr 24h Uur increased percentage and Sur reduced no significant difference (P> 0.05). No adverse reactions occurred. Conclusion In elderly patients with mild hypogonadism, Legionella can promote uric acid excretion and significantly reduce serum uric acid levels. Short-term application of no adverse reactions.