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目的分析鼠神经生长因子联合亚低温疗法治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法选取2012年1月-2016年1月佳县人民医院儿科住院的60例新生儿HIE患者,随机分为观察组和对照组,每组30例。对照组患儿给予常规综合治疗;观察组患儿给予常规综合治疗和亚低温疗法。观察两组患儿疗效和症状改善时间,患儿神经功能恢复时间,新生儿行为神经测定(NBNA)评分,智能发育指数(MDI)和运动发育指数(PDI)。结果观察组的总有效率(93.33%)明显高于对照组(70.00%),差异有统计学意义(χ~2=7.161,P=0.028)。对照组1例患儿因呼吸循环衰竭死亡。观察组患儿意识恢复、反射恢复、肌张力恢复时间及NBNA评分明显优于对照组,差异均有统计学意义(均P<0.05)。两组患儿MDI及PDI比较,差异均有统计学意义(均P<0.05)。结论鼠神经生长因子联合亚低温疗法治疗HIE疗效显著,安全性好,值得临床推广应用。
Objective To analyze the clinical effect of combined therapy of nystatin and mild hypothermia on neonatal hypoxic-ischemic encephalopathy (HIE). Methods Sixty neonates with HIE who were hospitalized in Jia County People’s Hospital from January 2012 to January 2016 were randomly divided into observation group and control group with 30 cases in each group. The control group of children given conventional comprehensive treatment; observation group of children given conventional comprehensive treatment and mild hypothermia therapy. The curative effect and symptom improvement time, neurologic functional recovery time, NBNA score, MDI and PDI in both groups were observed. Results The total effective rate (93.33%) in observation group was significantly higher than that in control group (70.00%), the difference was statistically significant (χ ~ 2 = 7.161, P = 0.028). One patient in the control group died of respiratory failure. The awareness recovery, reflex recovery, muscle tone recovery time and NBNA score in observation group were significantly better than those in control group (all P <0.05). The differences of MDI and PDI between the two groups were statistically significant (all P <0.05). Conclusion The combination of NGF and mild hypothermia is effective and safe in treating HIE, which deserves clinical application.